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Volume 61, issue 3 | Copyright
Arch. Anim. Breed., 61, 311-319, 2018
https://doi.org/10.5194/aab-61-311-2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.

Original study 26 Jul 2018

Original study | 26 Jul 2018

Detection of insertion/deletions (indels) of the ATBF1 gene and their effects on growth-related traits in three indigenous goat breeds

Zhenyu Wei1,*, Ke Wang1,*, Yiqing Hui1, Hailong Yan1,2,3, Haijing Zhu2,3, Lei Qu2,3, Chuanying Pan1, Hong Chen1, and Xianyong Lan1 Zhenyu Wei et al.
  • 1College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi, China
  • 2Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats,Yulin University, Yulin, China
  • 3Life Science Research Center, Yulin University, Yulin, China
  • *These authors contributed equally to this work.

Abstract. The AT motif-binding factor (ATBF1), also known as zinc finger homeobox 3 (ZFXH3), is necessary for activating the POU1F1 gene; thus, the ATBF1 gene greatly affects the grow traits in animals. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Two indels within the ATBF1 gene were found in the Shaanbei white cashmere goat (SWCG; n = 581), the Guanzhong dairy goat (GZDG; n = 334) and the Hainan black goat (HNBG; n = 270) for the first time using 12 pairs of primers. Association analysis revealed that the P1-12-bp indel was consistently correlated with the body height of the three breeds, and individuals with ID (insertion/deletion) and DD (deletion/deletion) genotypes had a higher body weight than the II (insertion/insertion) genotype (P = 0.036); the P11-6-bp indel was consistently correlated with chest circumference and hip width of the three breeds. Moreover, these two loci were associated with other several growth-related traits in different breeds. Hence, these findings indicated that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry by implementing marker-assisted selection (MAS).

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An effective DNA marker-assisted selection would speed up the development and improvement of goat products. The objective of this work was to explore novel indel (insertion/deletion) variations and their associations with growth traits in three native Chinese goat breeds. Results showed that the goat ATBF1 gene had marked effects on growth traits and the growth-trait-related loci, which would contribute to improving the growth-related traits of local breeds in the goat industry.
An effective DNA marker-assisted selection would speed up the development and improvement of...
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