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Arch. Anim. Breed., 61, 1-8, 2018
https://doi.org/10.5194/aab-61-1-2018
© Author(s) 2018. This work is distributed under
the Creative Commons Attribution 4.0 License.
Original study
04 Jan 2018
A novel 12 bp deletion within goat LHX4 gene significantly affected litter size
Hailong Yan1,2,3,*, Fei Zhang4,*, Ke Wang3, Jinwang Liu1,2, Haijing Zhu1,2, Chuanying Pan3, and Lei Qu1,2 1Shaanxi Provincial Engineering and Technology Research Center of Cashmere Goats, Yulin University, Yulin 719000, China
2Life Science Research Center, Yulin University, Yulin 719000, China
3College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, 712100 Shaanxi, China
4Innovation Experimental College, Northwest A&F University, Yangling 712100, China
*These authors contributed equally to this work.
Abstract. The LIM homeobox transcription factor 4 (LHX4) gene plays a critical role in regulating the development of the pituitary and the secretion of growth hormone (GH) and prolactin (PRL) associated with reproduction. Thus this gene may affect litter size. Herein, the aim of this study is to detect the novel insertion/deletion (indel) within the LHX4 gene as well as to test its association with litter size in 1149 Shaanbei white cashmere goats. Herein, a novel 12 bp indel (NC_030823.1:g.60001011_60001022delGGGGAGGAGGGG) was firstly found, which was located in the first intron. Meanwhile, three genotypes were detected in Shaanbei white cashmere goats, and the allelic frequencies of I and D were 0.593 and 0.407, respectively. Interestingly, the genotype distributions between mothers of single-lamb (n = 895) and multi-lamb (n = 254) groups within Shaanbei white cashmere goats were significantly different, implying that the 12 bp indel might affect the litter size. Furthermore, the association analysis was carried out to find out that the 12 bp indel was significantly associated with litter size in the analyzed goat population (P  <  0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II (P  <  0.05). These findings suggest that this locus could be considered as a genetic marker for goat breeding, enriching the research category of functional genome of goats.

Citation: Yan, H., Zhang, F., Wang, K., Liu, J., Zhu, H., Pan, C., and Qu, L.: A novel 12 bp deletion within goat LHX4 gene significantly affected litter size, Arch. Anim. Breed., 61, 1-8, https://doi.org/10.5194/aab-61-1-2018, 2018.
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Short summary
In this study, a novel 12 bp indel within the LHX4 gene first intron was firstly found. Meanwhile, the association analysis indicated that the 12 bp indel was significantly associated with litter size in 1149 Shaanbei cashmere goats (P < 0.05). The litter sizes of genotype DD and ID individuals were superior to those of genotype II, implying that the 12 bp indel might affect litter size. These results could provide a new insight into implementing marker-assisted selection in goat breeding.
In this study, a novel 12 bp indel within the LHX4 gene first intron was firstly found....
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