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Archives Animal Breeding Archiv Tierzucht

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Logo Leibniz Institute for Farm Animal Biology
Logo Leibniz Association
Arch. Anim. Breed., 60, 357-362, 2017
https://doi.org/10.5194/aab-60-357-2017
© Author(s) 2017. This work is distributed under
the Creative Commons Attribution 3.0 License.
Original study
06 Oct 2017
A combined genotype of three SNPs in the bovine gene is related to growth performance in Chinese cattle
Jieping Huang1,2, Qiuzhi Zheng1, Shuzhe Wang1, Qiongqiong Zhang1, Lijun Jiang1,2, Ruijie Hao1, Fen Li1,2, and Yun Ma1,2 1College of Life Sciences, Xinyang Normal University, Xinyang, Henan, China
2Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang, Henan, China
Abstract. PPARD is involved in multiple biological processes, especially for those associated with energy metabolism. PPARD regulates lipid metabolism through up-regulate expression of genes associating with adipogenesis. This makes PPARD a significant candidate gene for production traits of livestock animals. Association studies between PPARD polymorphisms and production traits have been reported in pigs but are limited for other animals, including cattle. Here, we investigated the expression profile and polymorphism of bovine PPARD as well as their association with growth traits in Chinese cattle. Our results showed that the highest expression of PPARD was detected in kidney, following by adipose, which is consistent with its involvement in energy metabolism. Three SNPs of PPARD were detected and used to undergo selection pressure according the result of Hardy–Weinberg equilibrium analysis (P < 0.05). Moreover, all of these SNPs showed moderate diversity (0.25 < PIC < 0.5), indicating their relatively high selection potential. Association analysis suggested that individuals with the GAAGTT combined genotype of three SNPs detected showed optimal values in all of the growth traits analyzed. These results revealed that the GAAGTT combined genotype of three SNPs detected in the bovine PPARD gene was a significant potential genetic marker for marker-assisted selection in Chinese cattle. However, this should be further verified in larger populations before being applied to breeding.

Citation: Huang, J., Zheng, Q., Wang, S., Zhang, Q., Jiang, L., Hao, R., Li, F., and Ma, Y.: A combined genotype of three SNPs in the bovine gene is related to growth performance in Chinese cattle, Arch. Anim. Breed., 60, 357-362, https://doi.org/10.5194/aab-60-357-2017, 2017.
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Short summary
We investigated the expression profile and polymorphism of bovine PPARD as well as their association with growth traits in Chinese cattle. Association analysis suggested that individuals with the GAAGTT combined genotype of three SNPs detected showed optimal values in all the growth traits analyzed. These results revealed that the GAAGTT combined genotype of three SNPs detected in the bovine PPARD gene was a significant potential genetic marker for marker-assisted selection in Chinese cattle.
We investigated the expression profile and polymorphism of bovine PPARD as well as their...
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