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Volume 59, issue 4
Arch. Anim. Breed., 59, 469–476, 2016
https://doi.org/10.5194/aab-59-469-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
Arch. Anim. Breed., 59, 469–476, 2016
https://doi.org/10.5194/aab-59-469-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.

Original study 21 Nov 2016

Original study | 21 Nov 2016

The 10 bp duplication insertion/deletion in the promoter region within paired box 7 gene is associated with growth traits in cattle

Yunyun Jin1, Hanfang Cai1, Jiming Liu2, Fengpeng Lin3, Xinglei Qi3, Yueyu Bai4, Chuzhao Lei1, Hong Chen1, and Xianyong Lan1 Yunyun Jin et al.
  • 1College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, P. R. China
  • 2Animal Husbandry Technology Promotion Station of Jiangxi, Nanchang, Jiangxi 330000, P. R. China
  • 3Xianan Cattle Technology Development Company, Biyang, Henan 463700, P. R. China
  • 4Animal Health Supervision in Henan Province, Zhengzhou, Henan 450008, P. R. China

Abstract. Paired box 7 (Pax7) gene, a member of the paired box gene family, plays a critical role in animal growth and muscle development, especially in cell proliferation and self-renewal. The aim of this study was to detect the 10 base pair (bp) duplication insertion/deletion (indel) in the promoter region within the bovine Pax7 gene as well as its association with growth traits. Herein, a total of 718 individuals from five Chinese cattle breeds were sampled and detected. The 10 bp duplication indel was found in these cattle breeds and there were three genotypes: II (insertion/insertion), ID (insertion/deletion), and DD (deletion/deletion). Moreover, this indel was significantly associated with the body weight in Xianan cattle (P = 0.006), the body height in Jinjiang cattle (P = 0.046), and the hip width in Pi'nan cattle (P = 0.020). Consistently, the individuals with II genotype showed better phenotypic traits than those with the other genotypes in these five breeds. These findings suggest that the 10 bp duplication indel within the bovine Pax7 gene could be considered as an effective DNA molecular marker that provides valuable theoretical basis for marker-assisted selection (MAS) in beef cattle in the future.

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Paired box 7 (Pax7) gene, a member of the paired box gene family, plays a critical role in animal growth and muscle development, especially in cell proliferation and self-renewal. In our study, the 10 bp duplication indel was detected in the promoter region within bovine Pax7 gene as well as its association with growth traits. This indel was significantly associated with the body weight in Xianan cattle, the body height in Jinjiang cattle, and the hip width in Pi'nan cattle.
Paired box 7 (Pax7) gene, a member of the paired box gene family, plays a critical role in...
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