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Volume 59, issue 1
Arch. Anim. Breed., 59, 151–157, 2016
https://doi.org/10.5194/aab-59-151-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.
Arch. Anim. Breed., 59, 151–157, 2016
https://doi.org/10.5194/aab-59-151-2016
© Author(s) 2016. This work is distributed under
the Creative Commons Attribution 3.0 License.

Original study 30 Mar 2016

Original study | 30 Mar 2016

A novel 17 bp indel in the SMAD3 gene alters transcription level, contributing to phenotypic traits in Chinese cattle

Tao Shi1, Wenwen Peng1, Jianyu Yan1, Hanfang Cai1, Xianyong Lan1, Chuzhao Lei1, Yueyu Bai2, and Hong Chen1 Tao Shi et al.
  • 1College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, 712100 Shaanxi, China
  • 2Animal Health Supervision in Henan Province, Zhengzhou, 450008 Henan, China

Abstract. SMAD3, the messenger of the transforming growth factor beta (TGF-β) signaling pathway, plays essential roles in myogenesis and osteogenesis and may relate to the regulation of body weight. In this study, a 17 bp indel (NC_007308: g.101893_101909insGAGGATGAGTGCTCCAG) in intron3 of the SMAD3 gene was detected in four Chinese cattle breeds (Qinchuan, Jiaxian, Nanyang and Caoyuan) by using DNA pool sequencing, and its effects on gene expression and growth traits were analyzed in Qinchuan and Caoyuan cattle. The results showed that the indel locus was significantly associated with SMAD3 transcriptional levels where II genotypes had a higher value than DD genotypes in Qinchuan (QC) cattle muscle tissue (P < 0.05). In addition, the locus was strongly associated with chest girth, chest width, rump length, hucklebone width and body weight in 2-year-old QC cattle (P < 0.05) and body weight (12 months), body height (18 months) and chest girth (18 months) in Caoyuan cattle (P < 0.5). To the best of our knowledge, this is the first evidence of the association between SMAD3 indel and cattle phenotype, and it may contribute to understanding the function of the indel, which could be a promising marker for beef cattle breeding.

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Short summary
SMAD3 plays essential roles in myogenesis and osteogenesis and may relate to the regulation of body weight. In this study, a 17 bp indel in intron3 of the SMAD3 gene was detected in four Chinese cattle breeds (Qinchuan, Jiaxian, Nanyang and Caoyuan) by using DNA pool sequencing, and it was significantly associated with gene expression and growth traits of Qinchuan and Caoyuan cattle. This indel could be could be a promising marker for beef cattle breeding.
SMAD3 plays essential roles in myogenesis and osteogenesis and may relate to the regulation of...
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